Development and Evaluation of Baclofen Based Topical Microemulsion

Abdulnasser Nasser Ali Mahdad, UshaG.K, S.Rajarajan, Tejas.R

Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might interfere with movement, speech, or be associated with discomfort or pain. Baclofen has significant pharmacokinetic drawbacks when taken orally because it has a short biological half-life of 3–4 hours and is absorbed in the upper small intestine making its duration of action limited. Patient failure to comply results from the requirement that it be taken often. Recent studies attempted to develop oral dosage forms of sustained release in response to all the prior restrictions of oral baclofen, but the efforts failed for a variety of reasons, including dose dumping. Baclofen is a great choice for transdermal drug delivery because of its excellent physical - chemical and biological data, which were obtained from the best sources.